{
  "metadata": {
    "title": "Gut Check: The Neuroscience of How Your Gut and Brain Talk",
    "description": "Learning graph of 337 concepts for a high-school gut-brain neuroscience textbook.",
    "creator": "Aaryav Sharma",
    "date": "2026-10-23",
    "version": "1.0",
    "format": "Learning Graph JSON v1.0",
    "schema": "https://raw.githubusercontent.com/dmccreary/learning-graphs/refs/heads/main/src/schema/learning-graph-schema.json",
    "license": "CC BY-NC-SA 4.0",
    "publisher": "Aaryav Sharma"
  },
  "groups": {
    "FOUND": {
      "classifierName": "Foundations",
      "color": "MistyRose",
      "font": {
        "color": "black"
      }
    },
    "ENS": {
      "classifierName": "Enteric Nervous System",
      "color": "PaleTurquoise",
      "font": {
        "color": "black"
      }
    },
    "VAGUS": {
      "classifierName": "Vagus and Nerve Pathways",
      "color": "Aquamarine",
      "font": {
        "color": "black"
      }
    },
    "MICRO": {
      "classifierName": "Microbiome and Diet",
      "color": "PaleGreen",
      "font": {
        "color": "black"
      }
    },
    "IMMUNE": {
      "classifierName": "Gut Immunity",
      "color": "LightSalmon",
      "font": {
        "color": "black"
      }
    },
    "CHEM": {
      "classifierName": "Messengers and Barriers",
      "color": "Plum",
      "font": {
        "color": "white"
      }
    },
    "STRESS": {
      "classifierName": "Stress and the HPA Axis",
      "color": "Khaki",
      "font": {
        "color": "black"
      }
    },
    "PAIN": {
      "classifierName": "Pain and Sensitivity",
      "color": "LightPink",
      "font": {
        "color": "black"
      }
    },
    "GIDIS": {
      "classifierName": "Gut Disorders",
      "color": "PeachPuff",
      "font": {
        "color": "black"
      }
    },
    "NEURO": {
      "classifierName": "Brain and Mental Health",
      "color": "LightSteelBlue",
      "font": {
        "color": "black"
      }
    },
    "TREAT": {
      "classifierName": "Tests and Treatments",
      "color": "LightCyan",
      "font": {
        "color": "black"
      }
    },
    "EVID": {
      "classifierName": "Evidence and Claim Checking",
      "color": "Wheat",
      "font": {
        "color": "black"
      }
    },
    "LIFE": {
      "classifierName": "Living With Illness",
      "color": "Thistle",
      "font": {
        "color": "black"
      }
    }
  },
  "nodes": [
    {
      "id": 1,
      "label": "Digestive Tract",
      "group": "FOUND",
      "shape": "box",
      "cis": 1012
    },
    {
      "id": 2,
      "label": "Gut Wall Layers",
      "group": "FOUND",
      "cis": 129
    },
    {
      "id": 3,
      "label": "Smooth Muscle",
      "group": "FOUND",
      "cis": 29
    },
    {
      "id": 4,
      "label": "Central Nervous System",
      "group": "FOUND",
      "shape": "box",
      "cis": 2260
    },
    {
      "id": 5,
      "label": "Peripheral Nervous System",
      "group": "FOUND",
      "cis": 1158
    },
    {
      "id": 6,
      "label": "Autonomic Nervous System",
      "group": "FOUND",
      "cis": 733
    },
    {
      "id": 7,
      "label": "Gut-Brain Axis",
      "group": "FOUND",
      "cis": 651
    },
    {
      "id": 8,
      "label": "Enteric Nervous System",
      "group": "ENS",
      "cis": 31
    },
    {
      "id": 9,
      "label": "Myenteric Plexus",
      "group": "ENS",
      "cis": 14
    },
    {
      "id": 10,
      "label": "Submucosal Plexus",
      "group": "ENS",
      "cis": 1
    },
    {
      "id": 11,
      "label": "Enteric Neuron",
      "group": "ENS",
      "cis": 7
    },
    {
      "id": 12,
      "label": "Enteric Glia",
      "group": "ENS",
      "cis": 1
    },
    {
      "id": 13,
      "label": "Interstitial Cells of Cajal",
      "group": "ENS",
      "cis": 2
    },
    {
      "id": 14,
      "label": "Peristalsis",
      "group": "ENS",
      "cis": 11
    },
    {
      "id": 15,
      "label": "Peristaltic Reflex",
      "group": "ENS",
      "cis": 2
    },
    {
      "id": 16,
      "label": "Migrating Motor Complex",
      "group": "ENS",
      "cis": 1
    },
    {
      "id": 17,
      "label": "ENS Neuron Count",
      "group": "ENS",
      "cis": 2
    },
    {
      "id": 18,
      "label": "Neural Crest",
      "group": "ENS",
      "cis": 2
    },
    {
      "id": 19,
      "label": "Hirschsprung Disease",
      "group": "GIDIS",
      "cis": 1
    },
    {
      "id": 20,
      "label": "Second Brain Metaphor",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 21,
      "label": "Hype Meter",
      "group": "EVID",
      "cis": 168
    },
    {
      "id": 22,
      "label": "Evidence Grade",
      "group": "EVID",
      "cis": 160
    },
    {
      "id": 23,
      "label": "Cranial Nerve",
      "group": "FOUND",
      "cis": 423
    },
    {
      "id": 24,
      "label": "Brainstem",
      "group": "FOUND",
      "cis": 88
    },
    {
      "id": 25,
      "label": "Sympathetic Nervous System",
      "group": "FOUND",
      "cis": 232
    },
    {
      "id": 26,
      "label": "Parasympathetic Nervous System",
      "group": "FOUND",
      "cis": 427
    },
    {
      "id": 27,
      "label": "Vagus Nerve",
      "group": "VAGUS",
      "cis": 422
    },
    {
      "id": 28,
      "label": "Afferent Signal",
      "group": "VAGUS",
      "cis": 395
    },
    {
      "id": 29,
      "label": "Efferent Signal",
      "group": "VAGUS",
      "cis": 10
    },
    {
      "id": 30,
      "label": "Nodose Ganglion",
      "group": "VAGUS",
      "cis": 2
    },
    {
      "id": 31,
      "label": "Nucleus Tractus Solitarius",
      "group": "VAGUS",
      "cis": 80
    },
    {
      "id": 32,
      "label": "Dorsal Motor Nucleus",
      "group": "VAGUS",
      "cis": 3
    },
    {
      "id": 33,
      "label": "Spinal Afferent Nerve",
      "group": "VAGUS",
      "cis": 230
    },
    {
      "id": 34,
      "label": "Interoception",
      "group": "VAGUS",
      "cis": 78
    },
    {
      "id": 35,
      "label": "Enteroendocrine Cell",
      "group": "CHEM",
      "cis": 11
    },
    {
      "id": 36,
      "label": "Neuropod Cell",
      "group": "CHEM",
      "cis": 1
    },
    {
      "id": 37,
      "label": "Gut Hormone",
      "group": "CHEM",
      "cis": 5
    },
    {
      "id": 38,
      "label": "Cholecystokinin",
      "group": "CHEM",
      "cis": 2
    },
    {
      "id": 39,
      "label": "GLP-1",
      "group": "CHEM",
      "cis": 2
    },
    {
      "id": 40,
      "label": "Satiety Signal",
      "group": "VAGUS",
      "cis": 1
    },
    {
      "id": 41,
      "label": "Vagal Tone",
      "group": "VAGUS",
      "cis": 4
    },
    {
      "id": 42,
      "label": "Vagotomy",
      "group": "VAGUS",
      "cis": 2
    },
    {
      "id": 43,
      "label": "Microorganism",
      "group": "FOUND",
      "shape": "box",
      "cis": 701
    },
    {
      "id": 44,
      "label": "Gut Microbiota",
      "group": "MICRO",
      "cis": 136
    },
    {
      "id": 45,
      "label": "Microbiome",
      "group": "MICRO",
      "cis": 8
    },
    {
      "id": 46,
      "label": "Bacterial Strain",
      "group": "MICRO",
      "cis": 86
    },
    {
      "id": 47,
      "label": "Commensal Bacteria",
      "group": "MICRO",
      "cis": 36
    },
    {
      "id": 48,
      "label": "Pathogen",
      "group": "MICRO",
      "cis": 366
    },
    {
      "id": 49,
      "label": "Microbial Diversity",
      "group": "MICRO",
      "cis": 64
    },
    {
      "id": 50,
      "label": "Dysbiosis",
      "group": "MICRO",
      "cis": 57
    },
    {
      "id": 51,
      "label": "Bacteria-to-Human Cell Ratio",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 52,
      "label": "Microbiome Development",
      "group": "MICRO",
      "cis": 5
    },
    {
      "id": 53,
      "label": "Birth Mode and Microbes",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 54,
      "label": "Human Milk Oligosaccharides",
      "group": "MICRO",
      "cis": 2
    },
    {
      "id": 55,
      "label": "Colonization Resistance",
      "group": "MICRO",
      "cis": 7
    },
    {
      "id": 56,
      "label": "Antibiotic Disruption",
      "group": "MICRO",
      "cis": 4
    },
    {
      "id": 57,
      "label": "16S rRNA Sequencing",
      "group": "EVID",
      "cis": 2
    },
    {
      "id": 58,
      "label": "Metagenomic Sequencing",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 59,
      "label": "Animal Model",
      "group": "EVID",
      "cis": 25
    },
    {
      "id": 60,
      "label": "Germ-Free Mouse",
      "group": "EVID",
      "cis": 5
    },
    {
      "id": 61,
      "label": "Correlation vs Causation",
      "group": "EVID",
      "cis": 52
    },
    {
      "id": 62,
      "label": "Defining a Healthy Microbiome",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 63,
      "label": "Innate Immunity",
      "group": "IMMUNE",
      "cis": 354
    },
    {
      "id": 64,
      "label": "Adaptive Immunity",
      "group": "IMMUNE",
      "cis": 122
    },
    {
      "id": 65,
      "label": "Intestinal Epithelium",
      "group": "IMMUNE",
      "cis": 55
    },
    {
      "id": 66,
      "label": "Mucus Layer",
      "group": "IMMUNE",
      "cis": 11
    },
    {
      "id": 67,
      "label": "Tight Junction",
      "group": "IMMUNE",
      "cis": 15
    },
    {
      "id": 68,
      "label": "Gut-Associated Lymphoid Tissue",
      "group": "IMMUNE",
      "cis": 24
    },
    {
      "id": 69,
      "label": "Pattern Recognition Receptor",
      "group": "IMMUNE",
      "cis": 112
    },
    {
      "id": 70,
      "label": "Inflammation",
      "group": "IMMUNE",
      "cis": 109
    },
    {
      "id": 71,
      "label": "Cytokine",
      "group": "IMMUNE",
      "cis": 20
    },
    {
      "id": 72,
      "label": "Interleukin-6",
      "group": "IMMUNE",
      "cis": 1
    },
    {
      "id": 73,
      "label": "Tumor Necrosis Factor",
      "group": "IMMUNE",
      "cis": 4
    },
    {
      "id": 74,
      "label": "Interleukin-1 Beta",
      "group": "IMMUNE",
      "cis": 2
    },
    {
      "id": 75,
      "label": "Regulatory T Cell",
      "group": "IMMUNE",
      "cis": 2
    },
    {
      "id": 76,
      "label": "Immune-to-Brain Signaling",
      "group": "IMMUNE",
      "cis": 3
    },
    {
      "id": 77,
      "label": "Circumventricular Organ",
      "group": "IMMUNE",
      "cis": 1
    },
    {
      "id": 78,
      "label": "Microglia",
      "group": "IMMUNE",
      "cis": 4
    },
    {
      "id": 79,
      "label": "Neuroinflammation",
      "group": "NEURO",
      "cis": 2
    },
    {
      "id": 80,
      "label": "Sickness Behavior",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 81,
      "label": "Synapse",
      "group": "FOUND",
      "cis": 64
    },
    {
      "id": 82,
      "label": "Neurotransmitter",
      "group": "CHEM",
      "cis": 61
    },
    {
      "id": 83,
      "label": "Serotonin",
      "group": "CHEM",
      "cis": 9
    },
    {
      "id": 84,
      "label": "Tryptophan",
      "group": "CHEM",
      "cis": 3
    },
    {
      "id": 85,
      "label": "Tryptophan Hydroxylase",
      "group": "CHEM",
      "cis": 1
    },
    {
      "id": 86,
      "label": "Enterochromaffin Cell",
      "group": "CHEM",
      "cis": 3
    },
    {
      "id": 87,
      "label": "Serotonin Transporter",
      "group": "CHEM",
      "cis": 2
    },
    {
      "id": 88,
      "label": "SSRI",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 89,
      "label": "Blood-Brain Barrier",
      "group": "CHEM",
      "cis": 3
    },
    {
      "id": 90,
      "label": "Gut Serotonin Mood Myth",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 91,
      "label": "Dopamine",
      "group": "CHEM",
      "cis": 16
    },
    {
      "id": 92,
      "label": "GABA",
      "group": "CHEM",
      "cis": 2
    },
    {
      "id": 93,
      "label": "Acetylcholine",
      "group": "CHEM",
      "cis": 1
    },
    {
      "id": 94,
      "label": "Microbe-Made Neurotransmitter",
      "group": "CHEM",
      "cis": 1
    },
    {
      "id": 95,
      "label": "Kynurenine Pathway",
      "group": "CHEM",
      "cis": 1
    },
    {
      "id": 96,
      "label": "Spore-Forming Bacteria",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 97,
      "label": "Dietary Fiber",
      "group": "MICRO",
      "cis": 30
    },
    {
      "id": 98,
      "label": "Fermentation",
      "group": "MICRO",
      "cis": 17
    },
    {
      "id": 99,
      "label": "Short-Chain Fatty Acid",
      "group": "MICRO",
      "cis": 10
    },
    {
      "id": 100,
      "label": "Butyrate",
      "group": "MICRO",
      "cis": 3
    },
    {
      "id": 101,
      "label": "Propionate",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 102,
      "label": "Acetate",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 103,
      "label": "Colonocyte",
      "group": "FOUND",
      "cis": 1
    },
    {
      "id": 104,
      "label": "Free Fatty Acid Receptor",
      "group": "CHEM",
      "cis": 1
    },
    {
      "id": 105,
      "label": "Gene Regulation by Butyrate",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 106,
      "label": "Intestinal Permeability",
      "group": "IMMUNE",
      "cis": 10
    },
    {
      "id": 107,
      "label": "Leaky Gut Claim",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 108,
      "label": "Zonulin",
      "group": "IMMUNE",
      "cis": 1
    },
    {
      "id": 109,
      "label": "Lipopolysaccharide",
      "group": "IMMUNE",
      "cis": 2
    },
    {
      "id": 110,
      "label": "Metabolic Endotoxemia",
      "group": "IMMUNE",
      "cis": 1
    },
    {
      "id": 111,
      "label": "Microglia Maturation",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 112,
      "label": "BBB Permeability",
      "group": "CHEM",
      "cis": 1
    },
    {
      "id": 113,
      "label": "Stress Response",
      "group": "STRESS",
      "cis": 42
    },
    {
      "id": 114,
      "label": "Fight-or-Flight Response",
      "group": "STRESS",
      "cis": 1
    },
    {
      "id": 115,
      "label": "Hypothalamus",
      "group": "FOUND",
      "cis": 104
    },
    {
      "id": 116,
      "label": "Pituitary Gland",
      "group": "FOUND",
      "cis": 72
    },
    {
      "id": 117,
      "label": "Adrenal Gland",
      "group": "FOUND",
      "cis": 46
    },
    {
      "id": 118,
      "label": "HPA Axis",
      "group": "STRESS",
      "cis": 25
    },
    {
      "id": 119,
      "label": "Corticotropin-Releasing Hormone",
      "group": "STRESS",
      "cis": 23
    },
    {
      "id": 120,
      "label": "ACTH",
      "group": "STRESS",
      "cis": 21
    },
    {
      "id": 121,
      "label": "Cortisol",
      "group": "STRESS",
      "cis": 20
    },
    {
      "id": 122,
      "label": "Negative Feedback",
      "group": "FOUND",
      "cis": 9
    },
    {
      "id": 123,
      "label": "Acute Stress",
      "group": "STRESS",
      "cis": 9
    },
    {
      "id": 124,
      "label": "Chronic Stress",
      "group": "STRESS",
      "cis": 8
    },
    {
      "id": 125,
      "label": "Stress and Gut Motility",
      "group": "STRESS",
      "cis": 1
    },
    {
      "id": 126,
      "label": "Mast Cell",
      "group": "IMMUNE",
      "cis": 6
    },
    {
      "id": 127,
      "label": "Early-Life Stress",
      "group": "STRESS",
      "cis": 1
    },
    {
      "id": 128,
      "label": "Germ-Free Stress Response",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 129,
      "label": "Nociceptor",
      "group": "PAIN",
      "cis": 71
    },
    {
      "id": 130,
      "label": "Somatic Pain",
      "group": "PAIN",
      "cis": 2
    },
    {
      "id": 131,
      "label": "Visceral Pain",
      "group": "PAIN",
      "cis": 67
    },
    {
      "id": 132,
      "label": "Referred Pain",
      "group": "PAIN",
      "cis": 1
    },
    {
      "id": 133,
      "label": "Dorsal Root Ganglion",
      "group": "PAIN",
      "cis": 84
    },
    {
      "id": 134,
      "label": "Dorsal Horn",
      "group": "PAIN",
      "cis": 83
    },
    {
      "id": 135,
      "label": "Thalamus",
      "group": "FOUND",
      "cis": 153
    },
    {
      "id": 136,
      "label": "Insula",
      "group": "PAIN",
      "cis": 76
    },
    {
      "id": 137,
      "label": "Anterior Cingulate Cortex",
      "group": "PAIN",
      "cis": 76
    },
    {
      "id": 138,
      "label": "Pain Perception",
      "group": "PAIN",
      "cis": 75
    },
    {
      "id": 139,
      "label": "Gate Control Theory",
      "group": "PAIN",
      "cis": 4
    },
    {
      "id": 140,
      "label": "Visceral Hypersensitivity",
      "group": "PAIN",
      "cis": 65
    },
    {
      "id": 141,
      "label": "Peripheral Sensitization",
      "group": "PAIN",
      "cis": 1
    },
    {
      "id": 142,
      "label": "Central Sensitization",
      "group": "PAIN",
      "cis": 3
    },
    {
      "id": 143,
      "label": "Descending Pain Modulation",
      "group": "PAIN",
      "cis": 3
    },
    {
      "id": 144,
      "label": "Balloon Distension Test",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 145,
      "label": "Pain Catastrophizing",
      "group": "PAIN",
      "cis": 5
    },
    {
      "id": 146,
      "label": "Immune-Mediated Disease",
      "group": "GIDIS",
      "cis": 85
    },
    {
      "id": 147,
      "label": "Inflammatory Bowel Disease",
      "group": "GIDIS",
      "cis": 63
    },
    {
      "id": 148,
      "label": "Ulcerative Colitis",
      "group": "GIDIS",
      "cis": 5
    },
    {
      "id": 149,
      "label": "Crohn's Disease",
      "group": "GIDIS",
      "cis": 5
    },
    {
      "id": 150,
      "label": "Transmural Inflammation",
      "group": "GIDIS",
      "cis": 1
    },
    {
      "id": 151,
      "label": "Disease Flare",
      "group": "GIDIS",
      "cis": 19
    },
    {
      "id": 152,
      "label": "Remission",
      "group": "GIDIS",
      "cis": 2
    },
    {
      "id": 153,
      "label": "Extraintestinal Manifestation",
      "group": "GIDIS",
      "cis": 1
    },
    {
      "id": 154,
      "label": "IBD Risk Factors",
      "group": "GIDIS",
      "cis": 4
    },
    {
      "id": 155,
      "label": "Pediatric IBD",
      "group": "GIDIS",
      "cis": 3
    },
    {
      "id": 156,
      "label": "Colonoscopy",
      "group": "TREAT",
      "cis": 2
    },
    {
      "id": 157,
      "label": "Fecal Calprotectin",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 158,
      "label": "Aminosalicylate",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 159,
      "label": "Corticosteroid",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 160,
      "label": "Immunomodulator",
      "group": "TREAT",
      "cis": 4
    },
    {
      "id": 161,
      "label": "Biologic Therapy",
      "group": "TREAT",
      "cis": 3
    },
    {
      "id": 162,
      "label": "Anti-TNF Therapy",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 163,
      "label": "JAK Inhibitor",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 164,
      "label": "Mucosal Healing",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 165,
      "label": "IBD Surgery",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 166,
      "label": "Gut-Brain Interaction Disorder",
      "group": "GIDIS",
      "cis": 60
    },
    {
      "id": 167,
      "label": "Structural vs Functional Disease",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 168,
      "label": "Irritable Bowel Syndrome",
      "group": "GIDIS",
      "cis": 57
    },
    {
      "id": 169,
      "label": "Rome IV Criteria",
      "group": "GIDIS",
      "cis": 5
    },
    {
      "id": 170,
      "label": "IBS Subtypes",
      "group": "GIDIS",
      "cis": 1
    },
    {
      "id": 171,
      "label": "Functional Dyspepsia",
      "group": "GIDIS",
      "cis": 1
    },
    {
      "id": 172,
      "label": "Post-Infection IBS",
      "group": "GIDIS",
      "cis": 1
    },
    {
      "id": 173,
      "label": "Alarm Features",
      "group": "TREAT",
      "cis": 2
    },
    {
      "id": 174,
      "label": "Positive Diagnosis Strategy",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 175,
      "label": "FODMAP",
      "group": "MICRO",
      "cis": 5
    },
    {
      "id": 176,
      "label": "Low-FODMAP Diet",
      "group": "TREAT",
      "cis": 3
    },
    {
      "id": 177,
      "label": "Cognitive Behavioral Therapy",
      "group": "TREAT",
      "cis": 4
    },
    {
      "id": 178,
      "label": "Gut-Directed Hypnotherapy",
      "group": "TREAT",
      "cis": 2
    },
    {
      "id": 179,
      "label": "Gut-Brain Neuromodulator",
      "group": "TREAT",
      "cis": 2
    },
    {
      "id": 180,
      "label": "Peppermint Oil",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 181,
      "label": "Placebo Response",
      "group": "EVID",
      "cis": 37
    },
    {
      "id": 182,
      "label": "Anxiety Disorder",
      "group": "NEURO",
      "cis": 26
    },
    {
      "id": 183,
      "label": "Major Depressive Disorder",
      "group": "NEURO",
      "cis": 32
    },
    {
      "id": 184,
      "label": "GI-Specific Anxiety",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 185,
      "label": "Psychiatric Comorbidity",
      "group": "NEURO",
      "cis": 18
    },
    {
      "id": 186,
      "label": "Bidirectional Relationship",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 187,
      "label": "Meta-Analysis",
      "group": "EVID",
      "cis": 37
    },
    {
      "id": 188,
      "label": "Symptom Questionnaire",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 189,
      "label": "Cohort Study",
      "group": "EVID",
      "cis": 7
    },
    {
      "id": 190,
      "label": "Reverse Causation",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 191,
      "label": "Confounding Variable",
      "group": "EVID",
      "cis": 38
    },
    {
      "id": 192,
      "label": "Inflammatory Depression Theory",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 193,
      "label": "Illness Burden",
      "group": "NEURO",
      "cis": 14
    },
    {
      "id": 194,
      "label": "Microbiota Transfer Study",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 195,
      "label": "Help-Seeking",
      "group": "NEURO",
      "cis": 6
    },
    {
      "id": 196,
      "label": "Crisis Resources",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 197,
      "label": "Integrated Care",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 198,
      "label": "Celiac Disease",
      "group": "GIDIS",
      "cis": 21
    },
    {
      "id": 199,
      "label": "Gluten",
      "group": "GIDIS",
      "cis": 9
    },
    {
      "id": 200,
      "label": "HLA-DQ2 and HLA-DQ8",
      "group": "GIDIS",
      "cis": 1
    },
    {
      "id": 201,
      "label": "Intestinal Villi",
      "group": "FOUND",
      "cis": 3
    },
    {
      "id": 202,
      "label": "Villous Atrophy",
      "group": "GIDIS",
      "cis": 2
    },
    {
      "id": 203,
      "label": "Tissue Transglutaminase Antibody",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 204,
      "label": "Small Bowel Biopsy",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 205,
      "label": "Gluten-Free Diet",
      "group": "TREAT",
      "cis": 3
    },
    {
      "id": 206,
      "label": "Gluten Ataxia",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 207,
      "label": "Peripheral Neuropathy",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 208,
      "label": "Non-Celiac Gluten Sensitivity",
      "group": "GIDIS",
      "cis": 2
    },
    {
      "id": 209,
      "label": "Fructan",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 210,
      "label": "Food Allergy",
      "group": "IMMUNE",
      "cis": 4
    },
    {
      "id": 211,
      "label": "Immunoglobulin E",
      "group": "IMMUNE",
      "cis": 1
    },
    {
      "id": 212,
      "label": "Food Intolerance",
      "group": "GIDIS",
      "cis": 2
    },
    {
      "id": 213,
      "label": "Lactose Intolerance",
      "group": "GIDIS",
      "cis": 1
    },
    {
      "id": 214,
      "label": "Unneeded Restrictive Diet",
      "group": "EVID",
      "cis": 2
    },
    {
      "id": 215,
      "label": "Autism",
      "group": "NEURO",
      "cis": 12
    },
    {
      "id": 216,
      "label": "ADHD",
      "group": "NEURO",
      "cis": 4
    },
    {
      "id": 217,
      "label": "Neurodiversity",
      "group": "NEURO",
      "cis": 3
    },
    {
      "id": 218,
      "label": "Identity-First Language",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 219,
      "label": "GI Symptoms in Autism",
      "group": "NEURO",
      "cis": 3
    },
    {
      "id": 220,
      "label": "Selective Eating",
      "group": "NEURO",
      "cis": 2
    },
    {
      "id": 221,
      "label": "Interoceptive Differences",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 222,
      "label": "Diet as Confounder",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 223,
      "label": "Maternal Immune Activation",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 224,
      "label": "Open-Label Trial",
      "group": "EVID",
      "cis": 36
    },
    {
      "id": 225,
      "label": "Placebo-Controlled Trial",
      "group": "EVID",
      "cis": 33
    },
    {
      "id": 226,
      "label": "Sample Size",
      "group": "EVID",
      "cis": 9
    },
    {
      "id": 227,
      "label": "Microbiota Transfer Therapy",
      "group": "TREAT",
      "cis": 2
    },
    {
      "id": 228,
      "label": "Harmful Cure Claims",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 229,
      "label": "Neurodegeneration",
      "group": "NEURO",
      "cis": 18
    },
    {
      "id": 230,
      "label": "Parkinson's Disease",
      "group": "NEURO",
      "cis": 15
    },
    {
      "id": 231,
      "label": "Dopamine Neuron Loss",
      "group": "NEURO",
      "cis": 2
    },
    {
      "id": 232,
      "label": "Alpha-Synuclein",
      "group": "NEURO",
      "cis": 9
    },
    {
      "id": 233,
      "label": "Lewy Body",
      "group": "NEURO",
      "cis": 7
    },
    {
      "id": 234,
      "label": "Prodromal Symptoms",
      "group": "NEURO",
      "cis": 3
    },
    {
      "id": 235,
      "label": "Constipation",
      "group": "GIDIS",
      "cis": 2
    },
    {
      "id": 236,
      "label": "Braak Hypothesis",
      "group": "NEURO",
      "cis": 6
    },
    {
      "id": 237,
      "label": "Prion-Like Spread",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 238,
      "label": "Gut-First Subtype",
      "group": "NEURO",
      "cis": 2
    },
    {
      "id": 239,
      "label": "Brain-First Subtype",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 240,
      "label": "Truncal Vagotomy Studies",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 241,
      "label": "Appendix and Parkinson's",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 242,
      "label": "Levodopa Absorption",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 243,
      "label": "Alzheimer's Disease",
      "group": "NEURO",
      "cis": 2
    },
    {
      "id": 244,
      "label": "Amyloid Beta",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 245,
      "label": "Dietary Pattern",
      "group": "MICRO",
      "cis": 9
    },
    {
      "id": 246,
      "label": "Mediterranean Diet",
      "group": "TREAT",
      "cis": 2
    },
    {
      "id": 247,
      "label": "Ultra-Processed Food",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 248,
      "label": "Dietary Fiber Gap",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 249,
      "label": "Fermented Food",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 250,
      "label": "Polyphenol",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 251,
      "label": "Nutritional Psychiatry",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 252,
      "label": "Observational Study",
      "group": "EVID",
      "cis": 3
    },
    {
      "id": 253,
      "label": "Randomized Controlled Trial",
      "group": "EVID",
      "cis": 32
    },
    {
      "id": 254,
      "label": "SMILES Trial",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 255,
      "label": "Dose-Response Relationship",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 256,
      "label": "Healthy User Bias",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 257,
      "label": "Mediator Variable",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 258,
      "label": "Food Insecurity",
      "group": "LIFE",
      "cis": 1
    },
    {
      "id": 259,
      "label": "Eating Disorder Risk",
      "group": "NEURO",
      "cis": 1
    },
    {
      "id": 260,
      "label": "Probiotic",
      "group": "TREAT",
      "cis": 15
    },
    {
      "id": 261,
      "label": "Prebiotic",
      "group": "TREAT",
      "cis": 2
    },
    {
      "id": 262,
      "label": "Synbiotic",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 263,
      "label": "Postbiotic",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 264,
      "label": "Psychobiotic",
      "group": "TREAT",
      "cis": 2
    },
    {
      "id": 265,
      "label": "Lactobacillus",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 266,
      "label": "Bifidobacterium",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 267,
      "label": "Strain Specificity",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 268,
      "label": "Colony-Forming Unit",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 269,
      "label": "Dietary Supplement Regulation",
      "group": "TREAT",
      "cis": 5
    },
    {
      "id": 270,
      "label": "Probiotic Safety",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 271,
      "label": "Systematic Review",
      "group": "EVID",
      "cis": 3
    },
    {
      "id": 272,
      "label": "Effect Size",
      "group": "EVID",
      "cis": 8
    },
    {
      "id": 273,
      "label": "Primary Outcome",
      "group": "EVID",
      "cis": 2
    },
    {
      "id": 274,
      "label": "Publication Bias",
      "group": "EVID",
      "cis": 2
    },
    {
      "id": 275,
      "label": "Replication Failure",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 276,
      "label": "C. difficile Infection",
      "group": "GIDIS",
      "cis": 3
    },
    {
      "id": 277,
      "label": "Fecal Microbiota Transplant",
      "group": "TREAT",
      "cis": 2
    },
    {
      "id": 278,
      "label": "Live Biotherapeutic Product",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 279,
      "label": "FDA Approval",
      "group": "TREAT",
      "cis": 12
    },
    {
      "id": 280,
      "label": "Clinical Trial Phases",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 281,
      "label": "Off-Label Use",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 282,
      "label": "Benefit-Risk Balance",
      "group": "TREAT",
      "cis": 4
    },
    {
      "id": 283,
      "label": "Vagus Nerve Stimulation",
      "group": "TREAT",
      "cis": 5
    },
    {
      "id": 284,
      "label": "Implanted VNS Device",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 285,
      "label": "Noninvasive VNS",
      "group": "TREAT",
      "cis": 2
    },
    {
      "id": 286,
      "label": "Inflammatory Reflex",
      "group": "VAGUS",
      "cis": 2
    },
    {
      "id": 287,
      "label": "Bioelectronic Medicine",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 288,
      "label": "Consumer Wellness Device",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 289,
      "label": "Tricyclic Antidepressant",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 290,
      "label": "Shared Decision-Making",
      "group": "TREAT",
      "cis": 3
    },
    {
      "id": 291,
      "label": "Precision Medicine",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 292,
      "label": "Circadian Rhythm",
      "group": "NEURO",
      "cis": 6
    },
    {
      "id": 293,
      "label": "Sleep Architecture",
      "group": "NEURO",
      "cis": 4
    },
    {
      "id": 294,
      "label": "Teen Sleep Need",
      "group": "NEURO",
      "cis": 2
    },
    {
      "id": 295,
      "label": "Sleep and Inflammation",
      "group": "IMMUNE",
      "cis": 1
    },
    {
      "id": 296,
      "label": "Microbiome Daily Rhythm",
      "group": "MICRO",
      "cis": 1
    },
    {
      "id": 297,
      "label": "Sleep Hygiene",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 298,
      "label": "Physical Activity",
      "group": "TREAT",
      "cis": 3
    },
    {
      "id": 299,
      "label": "Exercise and Gut Transit",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 300,
      "label": "Exercise and Mood",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 301,
      "label": "Psychotherapy",
      "group": "TREAT",
      "cis": 3
    },
    {
      "id": 302,
      "label": "Brain-Gut Psychotherapy",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 303,
      "label": "Mindfulness",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 304,
      "label": "Slow Breathing",
      "group": "TREAT",
      "cis": 2
    },
    {
      "id": 305,
      "label": "Heart Rate Variability",
      "group": "VAGUS",
      "cis": 1
    },
    {
      "id": 306,
      "label": "Self-Monitoring",
      "group": "TREAT",
      "cis": 2
    },
    {
      "id": 307,
      "label": "Behavior Change",
      "group": "TREAT",
      "cis": 1
    },
    {
      "id": 308,
      "label": "Stigma",
      "group": "LIFE",
      "cis": 11
    },
    {
      "id": 309,
      "label": "Self-Stigma",
      "group": "LIFE",
      "cis": 2
    },
    {
      "id": 310,
      "label": "Mental Health Stigma",
      "group": "LIFE",
      "cis": 2
    },
    {
      "id": 311,
      "label": "Illness Concealment",
      "group": "LIFE",
      "cis": 3
    },
    {
      "id": 312,
      "label": "Quality of Life",
      "group": "LIFE",
      "cis": 2
    },
    {
      "id": 313,
      "label": "Health Literacy",
      "group": "LIFE",
      "cis": 7
    },
    {
      "id": 314,
      "label": "Family Communication",
      "group": "LIFE",
      "cis": 3
    },
    {
      "id": 315,
      "label": "Caregiver Role",
      "group": "LIFE",
      "cis": 1
    },
    {
      "id": 316,
      "label": "Global IBD Rise",
      "group": "GIDIS",
      "cis": 3
    },
    {
      "id": 317,
      "label": "Migration and IBD Risk",
      "group": "GIDIS",
      "cis": 2
    },
    {
      "id": 318,
      "label": "South Asian Health Context",
      "group": "LIFE",
      "cis": 1
    },
    {
      "id": 319,
      "label": "Help-Seeking Barriers",
      "group": "LIFE",
      "cis": 1
    },
    {
      "id": 320,
      "label": "Talking to Your Doctor",
      "group": "LIFE",
      "cis": 1
    },
    {
      "id": 321,
      "label": "School Accommodation",
      "group": "LIFE",
      "cis": 2
    },
    {
      "id": 322,
      "label": "504 Plan",
      "group": "LIFE",
      "cis": 1
    },
    {
      "id": 323,
      "label": "Peer Support",
      "group": "LIFE",
      "cis": 1
    },
    {
      "id": 324,
      "label": "Hierarchy of Evidence",
      "group": "EVID",
      "cis": 16
    },
    {
      "id": 325,
      "label": "Mouse-to-Human Translation",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 326,
      "label": "Peer Review",
      "group": "EVID",
      "cis": 10
    },
    {
      "id": 327,
      "label": "Preprint",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 328,
      "label": "Conflict of Interest",
      "group": "EVID",
      "cis": 3
    },
    {
      "id": 329,
      "label": "Preregistration",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 330,
      "label": "Statistical Significance",
      "group": "EVID",
      "cis": 7
    },
    {
      "id": 331,
      "label": "Absolute vs Relative Risk",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 332,
      "label": "Health Claim Marketing",
      "group": "EVID",
      "cis": 2
    },
    {
      "id": 333,
      "label": "Structure-Function Claim",
      "group": "EVID",
      "cis": 1
    },
    {
      "id": 334,
      "label": "Reading an Abstract",
      "group": "EVID",
      "cis": 5
    },
    {
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